DO calibration via Sed. Diagenesis Algorithm

I am looking for the most sensitive parameter(parameters) in sed. diagenesis module to calibrate DO. My calibration is great when I use zero order SOD but when I switched simulation to Diagenesis and turned off Zero and 1st order rates, the model is over predicting DO. Attempting to change some parameters one at a time didn't easily fix my DO over prediction. Any input is appreciated. Thanks in advance.